rs591058

A SNP in the MMP3 gene on chromosome 11. Its most notable genotype is C;C: higher risk for Achilles tendinopathy?

Gene
MMP3
Location
Chr 11102,840,607 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedhigher risk for Achilles tendinopathy?Minor · 1.043% of people
  2. T;TGoodcommon in clinvarTypical · 0.014% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 43% T;T 14%
  • European ancestry (Utah)C;C 19% T;T 30%
  • Han Chinese (Beijing)C;C 47% T;T 11%
  • Japanese (Tokyo)C;C 53% T;T 8%
  • Yoruba (Nigeria)C;C 37% T;T 14%
  • African ancestry (Southwest US)C;C 40% T;T 12%
  • Chinese (Denver)C;C 44% T;T 14%
  • Gujarati IndianC;C 57% T;T 7%
  • Luhya (Kenya)C;C 62% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 43% T;T 12%
  • Maasai (Kenya)C;C 41% T;T 12%
  • TuscanC;C 29% T;T 24%

Other MMP3 SNPs

All MMP3 SNPs

Notes

From SNPedia

Notes

rs591058 is a SNP in the matrix metallopeptidase 3 MMP3 gene on ch 11. A relatively small study (~100 patients) found associations between risk for Achilles tendinopathy and SNPs in the MMP3 gene. For rs591058, the (C;C) genotype had an odds ratio of 2.3 (CI: 1.1 to 4.50, p = 0.023).

Source and license

Adapted from rs591058 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.