rs650108

A SNP in the MMP3 gene on chromosome 11. Its most notable genotype is A;A: higher risk for Achilles tendinopathy?

Gene
MMP3
Location
Chr 11102,838,056 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
41%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedhigher risk for Achilles tendinopathy?Minor · 1.022% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 22%
  • European ancestry (Utah)A;A 5%
  • Han Chinese (Beijing)A;A 38%
  • Japanese (Tokyo)A;A 38%
  • Yoruba (Nigeria)A;A 10%

Other MMP3 SNPs

All MMP3 SNPs

Notes

From SNPedia

Notes

rs650108 is a SNP in the matrix metallopeptidase 3 MMP3 gene on ch 11. A relatively small study (~100 patients) found associations between risk for Achilles tendinopathy and SNPs in the MMP3 gene. For rs650108, the (A;A) genotype had an odds ratio of 4.9 (CI: 1.0 to 24.1, p = 0.043).

Source and license

Adapted from rs650108 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.