rs679620

A SNP in the MMP3 gene on chromosome 11. Its most notable genotype is C;C: higher risk for Achilles tendinopathy?

Gene
MMP3
Location
Chr 11102,842,889 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.014% of people
  2. C;CMost notableNot ratedhigher risk for Achilles tendinopathy?Minor · 1.039% of people

SNPedia records rs679620 on the minus strand: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageT;T 14% C;C 39%
  • European ancestry (Utah)T;T 32% C;C 16%
  • Han Chinese (Beijing)T;T 13% C;C 51%
  • Japanese (Tokyo)T;T 7% C;C 52%
  • Yoruba (Nigeria)T;T 11% C;C 33%
  • African ancestry (Southwest US)T;T 11% C;C 36%
  • Chinese (Denver)T;T 15% C;C 40%
  • Gujarati IndianT;T 7% C;C 54%
  • Maasai (Kenya)T;T 9% C;C 46%
  • TuscanT;T 25% C;C 26%

Other MMP3 SNPs

All MMP3 SNPs

Notes

From SNPedia

Show notes, about 140 words

A study of 1418 African-American women and men from the Genetic Epidemiology Network of Arteriopathy study found a significant sex-specific interaction effect between rs679620, a SNP in the metallopeptidase 3 MMP3 gene and body mass index (BMI) in African-American women but not men (p = 0.0009). rs679620 appears to have a protective effect on diastolic blood pressure in women with high BMI, but surprisingly, it had the opposite effect on women with low BMI, resulting in higher diastolic BP. A relatively small study (~100 patients) found associations between risk for Achilles tendinopathy and SNPs in the MMP3 gene. For rs679620, the (G;G) genotype had an odds ratio of 2.5 (CI: 1.2 - 4.90, p = 0.010). An interaction resulting in increased risk for Achilles tendinopathy was also reported between the rs679620(G) and COL5A1 rs12722(T) alleles (p = 0.006).

Source and license

Adapted from rs679620 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.