rs606231220
A SNP in the GRN gene on chromosome 17. Its most notable genotype is -;CCTG: Frontotemporal dementia mutation
- Gene
- GRN
- Location
- Chr 1744,349,260 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon in clinvar
- -;CCTGMost notableBadFrontotemporal dementia mutation
On SNPedia: (-;-), (-;CCTG). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other GRN SNPs
- rs193026789A;CFrontotemporal dementia mutationVery important
- rs606231221A;GFrontotemporal dementia mutationVery important
- rs794729669C;GFrontotemporal dementia mutationVery important
- rs794729670G;TFrontotemporal dementia mutationVery important
- rs794729671-;TFrontotemporal dementia mutationVery important
- rs794729672-;CFrontotemporal dementia mutationVery important
- rs63751243A;CLikely miscall in both 23andMe and Ancestry data; otherwise, possible frontotemporal dementia mutationImportant
- rs5848T;TSomewhat increased (~2 - 3x) dementia riskImportant
Notes
From SNPedia
Notes
rs606231220, also known as c.93_96dupCCTG and p.Asp33Profs, represents a very rare mutation in the GRN gene on chromosome 17. The rs606231220(CCTG) allele is reported in ClinVar as a dominant mutation pathogenic for frontotemporal dementia.
-;CCTG
see discussion at rs606231220 and at frontotemporal dementia
Source and license
Adapted from rs606231220 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.