rs606231221
A SNP in the GRN gene on chromosome 17. Its most notable genotype is A;G: Frontotemporal dementia mutation
- Gene
- GRN
- Location
- Chr 1744,351,164 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadFrontotemporal dementia mutation
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other GRN SNPs
- rs193026789A;CFrontotemporal dementia mutationVery important
- rs606231220-;CCTGFrontotemporal dementia mutationVery important
- rs794729669C;GFrontotemporal dementia mutationVery important
- rs794729670G;TFrontotemporal dementia mutationVery important
- rs794729671-;TFrontotemporal dementia mutationVery important
- rs794729672-;CFrontotemporal dementia mutationVery important
- rs63751243A;CLikely miscall in both 23andMe and Ancestry data; otherwise, possible frontotemporal dementia mutationImportant
- rs5848T;TSomewhat increased (~2 - 3x) dementia riskImportant
Notes
From SNPedia
Notes
rs606231221, also known as c.835+1G>A, represents a very rare mutation in the GRN gene on chromosome 17. The rs606231221(CCTG) allele is reported in ClinVar as a dominant mutation pathogenic for frontotemporal dementia.
A;G
see discussion at rs606231221 and at frontotemporal dementia
Source and license
Adapted from rs606231221 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.