rs61753344
A SNP in the FMO3 gene on chromosome 1. Its most notable genotype is T;T: trimethylaminuria & possible related issues
- Gene
- FMO3
- Location
- Chr 1171,114,092 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- G;TBadtrimethylaminuria, to varying degrees
- T;TMost notableBadtrimethylaminuria & possible related issues
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other FMO3 SNPs
- rs72549320A;Atrimethylaminuria & possible related issues; see discussionWorth knowing
- rs72549321A;Atrimethylaminuria & possible related issues; see discussionWorth knowing
- rs72549322G;Gtrimethylaminuria & possible related issues; see discussionWorth knowing
- rs72549323C;Cpossible trimethylaminuria; see discussionWorth knowing
- rs72549326T;Ttrimethylaminuria & possible related issues; see discussionWorth knowing
- rs72549330T;Ttrimethylaminuria & related issues; see discussionWorth knowing
- rs72549331T;Ttrimethylaminuria & related issues; see discussionWorth knowing
- rs72549332A;Atrimethylaminuria & possible related issues; see discussionWorth knowing
Notes
From SNPedia
Notes
rs61753344 is a SNP in the FMO3 gene. It has been reported in both homozygous and heterozygous forms to potentially be linked to trimethylaminuria; in the homozygous form, it has also been linked to tachycardia and severe hypertension after eating cheese (which contains tyramine) and after using nasal epinephrine.
T;T
See variant .0001 at OMIM; OMIM 136132.0001
Source and license
Adapted from rs61753344 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.