rs6495446

A SNP in the MTHFS gene on chromosome 15. Its most notable genotype is T;T: 0.64x reduced risk for chronic kidney disease

Gene
MTHFS
Location
Chr 1579,862,640 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadnormal, but increased risk for chronic kidney diseaseMinor · 1.048% of people
  2. C;TGood0.8x reduced risk for chronic kidney diseaseMinor · 1.440% of people
  3. T;TMost notableGood0.64x reduced risk for chronic kidney diseaseWorth knowing · 2.011% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 48% C;T 40% T;T 11%
  • European ancestry (Utah)C;C 62% C;T 36% T;T 3%
  • Han Chinese (Beijing)C;C 53% C;T 40% T;T 7%
  • Japanese (Tokyo)C;C 58% C;T 39% T;T 3%
  • Yoruba (Nigeria)C;C 26% C;T 50% T;T 24%
  • African ancestry (Southwest US)C;C 28% C;T 56% T;T 16%
  • Chinese (Denver)C;C 57% C;T 40% T;T 3%
  • Gujarati IndianC;C 72% C;T 23% T;T 5%
  • Luhya (Kenya)C;C 28% C;T 42% T;T 31%
  • Mexican ancestry (Los Angeles)C;C 61% C;T 32% T;T 7%
  • Maasai (Kenya)C;C 33% C;T 45% T;T 22%
  • TuscanC;C 53% C;T 42% T;T 6%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6495446, an intronic SNP in the MTHFS gene, was associated with increased risk for chronic kidney disease based on a study associated with the Framingham Heart Study of ~1,000 Caucasian individuals. The odds ratio rs6495446(C) allele was 1.24 (CI: 1.09-1.41, p=0.001).news 23andMe reports this same information with a different emphasis since the T allele is the minor allele in both European and Asian populations: each T allele lowers the odds of chronic kidney disease by 0.8 times.

C;C

in a small unreplicated study

Source and license

Adapted from rs6495446 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.