rs6746030

A SNP in the LOC101929680 gene on chromosome 2. Its most notable genotype is A;A: Increased perception of pain

Gene
LOC101929680
Location
Chr 2166,242,648 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadIncreased perception of painMinor · 1.0<1% of people
  2. A;GNot ratedreported to influence perception of painMinor · 1.018% of people
  3. G;GGoodNormal perception of painTypical · 0.081% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A <1% A;G 18% G;G 81%
  • European ancestry (Utah)A;A <1% A;G 22% G;G 77%
  • Han Chinese (Beijing)A;A 0% A;G 11% G;G 89%
  • Japanese (Tokyo)A;A 0% A;G 9% G;G 91%
  • Yoruba (Nigeria)A;A 1% A;G 25% G;G 73%
  • African ancestry (Southwest US)A;A 0% A;G 26% G;G 74%
  • Chinese (Denver)A;A 0% A;G 7% G;G 93%
  • Gujarati IndianA;A 4% A;G 29% G;G 67%
  • Luhya (Kenya)A;A <1% A;G 13% G;G 86%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 16% G;G 85%
  • Maasai (Kenya)A;A 0% A;G 21% G;G 80%
  • TuscanA;A 2% A;G 24% G;G 75%

Conditions, medicines and genes

Other LOC101929680 SNPs

All LOC101929680 SNPs

Notes

From SNPedia

Notes

rs6746030 is a SNP in the sodium channel Nav1.7 SCN9A gene. In five cohorts tested, totaling 1,277 individuals, the rarer rs6746030(A) allele was associated with increased pain (p=0.0001).

A;A

sciencemag news or the original paper

References

Source and license

Adapted from rs6746030 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.