rs121908910

A SNP in the LOC101929680 gene on chromosome 2. Its most notable genotype is A;A: Congenital insensitivity to pain

Gene
LOC101929680
Location
Chr 2166,272,731 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. A;GBadcarrier of one allele for insensitivity to painImportant · 3.0
  3. A;AMost notableBadCongenital insensitivity to painVery important · 4.0

SNPedia records rs121908910 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LOC101929680 SNPs

All LOC101929680 SNPs

Notes

From SNPedia

Notes

rs121908910, also known as c.2986C>T, p.Arg996Cys and R996C, is a rare mutation in the SCN9A gene on chromosome 2. Inherited in a recessive manner, the homozygous minor genotype for this SNP is reported to result in insensitivity to pain.

A;G

see discussion at rs121908910

A;A

see discussion at rs121908910

Source and license

Adapted from rs121908910 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.