rs121908917

A SNP in the LOC101929680 gene on chromosome 2. Its most notable genotype is T;T: Congenital insensitivity to pain

Gene
LOC101929680
Location
Chr 2166,293,354 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadCongenital insensitivity to painVery important · 4.0
  2. G;TBadcarrier of one allele for insensitivity to painImportant · 3.0
  3. G;GGoodcommon in clinvarTypical · 0.0

SNPedia records rs121908917 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LOC101929680 SNPs

All LOC101929680 SNPs

Notes

From SNPedia

Notes

rs121908917, also known as c.984C>A, p.Tyr328Ter and Y328X, is a rare mutation in the SCN9A gene on chromosome 2. Inherited in a recessive manner, the homozygous minor genotype for this SNP is reported to result in insensitivity to pain.

T;T

see discussion at rs121908917

G;T

see discussion at rs121908917

Source and license

Adapted from rs121908917 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.