rs6994992

also known as SNP8NRG243177 Initial reports of a link to schizophrenia remain inconclusive. paper implicated in schizophrenia effects white matter density and integrity schizophrenia risk-associated The neuregulin 1 promoter polymorphism rs6994992 is not associated with neurocognition or chronic schizophrenia in a study of 738 patients T allele (in a per allele fashion) significantly associated with lateral ventricle volume in 95 first-episode schizophrenics points out that their result is that (T) was weakly associated with schizophrenia, however this is the opposite of the original association study where the C allele.

C;T

Carrier for rs6994992(T;T) which one report has associated with both creativity and schizophrenia

T;T

Associated with creativity (or at least people who answer ads asking for people who believe they have high creativity) in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the (T;T) genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation. omim rs6994992 in 5-prime promoter region of the NRG1 gene regulates expression of the NRG1 type IV isoform. The T allele, which is the schizophrenia risk allele, showed a 65% increase in promoter activity. newscientist reports that this variation has been linked to psychosis, poor memory and sensitivity to criticism. About 50 per cent of healthy Europeans have one copy of this mutation, while 15 per cent possess two copies.