rs6996585

A SNP in the NRG1 gene on chromosome 8. Its most notable genotype is A;A: common/normal

Gene
NRG1
Location
Chr 832,543,285 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon/normalTypical · 0.048% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 48%
  • European ancestry (Utah)A;A 33%
  • Han Chinese (Beijing)A;A 64%
  • Japanese (Tokyo)A;A 51%
  • Yoruba (Nigeria)A;A 55%
  • African ancestry (Southwest US)A;A 51%
  • Chinese (Denver)A;A 60%
  • Gujarati IndianA;A 28%
  • Luhya (Kenya)A;A 67%
  • Mexican ancestry (Los Angeles)A;A 24%
  • Maasai (Kenya)A;A 52%
  • TuscanA;A 37%

Conditions, medicines and genes

Other NRG1 SNPs

All NRG1 SNPs

Notes

From SNPedia

Notes

GWAS and a replication study in Koreans using a total of 1,085 thyroid cancer cases and 8,884 controls observed the most robust associations were observed for rs6996585, an NRG1 gene SNP. The odds ratio for the risk allele, rs6996585(G), was ~1.3 as replicated.

Source and license

Adapted from rs6996585 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.