rs730880922
A SNP in the MYH7 gene on chromosome 14. Its most notable genotype is A;C: Hypertrophic Cardiomyopathy possible
- Gene
- MYH7
- Location
- Chr 1423,431,474 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- A;CMost notableBadHypertrophic Cardiomyopathy possible
- A;AGoodcommon in clinvar
SNPedia records rs730880922 on the minus strand: (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MYH7 SNPs
- rs121913633C;THypertrophic CardiomyopathyVery important
- rs267606908C;THypertrophic CardiomyopathyVery important
- rs397516212A;CHypertrophic CardiomyopathyVery important
- rs2069544G;TFamilial Hypertrophic CardiomyopathyVery important
- rs3218713A;CFamilial Hypertrophic CardiomyopathyVery important
- rs3218714C;GFamilial Hypertrophic CardiomyopathyVery important
- rs36211715C;TFamilial Hypertrophic CardiomyopathyVery important
- rs45611033A;GFamilial Hypertrophic CardiomyopathyVery important
Notes
From SNPedia
Notes
Invitae Labs has seen this variant in several people with Hypertrophic Cardiomyopathy. All ClinVar submitters believe this variant to be pathogenic based on computer modeling and similar variants in this region are pathogenic. ncbi.nlm.nih.gov
Source and license
Adapted from rs730880922 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.