rs75086406
A SNP in the FH gene on chromosome 1. Its most notable genotype is C;G: Associated with leiomyomatosis and possibly renal cell cancer
- Gene
- FH
- Location
- Chr 1241,513,679 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- Not on consumer chips
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in complete genomics
- C;GMost notableBadAssociated with leiomyomatosis and possibly renal cell cancer
- C;CGoodcommon in clinvar
SNPedia records rs75086406 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other FH SNPs
- rs367543046AAA;AAAFumarase deficiency (predicted)Very important
- rs121913120A;GHereditary leiomyomatosis and renal cell cancerVery important
- rs121913121G;TAssociated with leiomyomatosis and possibly renal cell cancerVery important
- rs121913122A;GHereditary leiomyomatosis and renal cell cancerVery important
- rs121913123C;TAssociated with leiomyomatosis and possibly renal cell cancerVery important
- rs387906546G;TAssociated with leiomyomatosis and possibly renal cell cancerVery important
- rs398123160A;GHereditary leiomyomatosis and renal cell cancerVery important
- rs398123163-;THereditary leiomyomatosis and renal cell cancerVery important
Notes
From SNPedia
Notes
C;G
see Hereditary leiomyomatosis and renal cell cancer
Source and license
Adapted from rs75086406 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.