rs757583846
A SNP in the PROC gene on chromosome 2. Its most notable genotype is T;T: Complete protein-C deficiency; severe thrombophilia
- Gene
- PROC
- Location
- Chr 2127,421,381 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TBadPartial protein-C deficiency; higher risk for blood clotting related issues
- T;TMost notableBadComplete protein-C deficiency; severe thrombophilia
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PROC SNPs
- rs121918141T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918142C;CComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918143T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918144T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918146A;AComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918147A;AComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918148C;CComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918149A;AComplete protein-C deficiency; severe thrombophiliaVery important
Notes
From SNPedia
Notes
aka c.169C>T (p.Arg57Trp) 23andMe name: i6017049, however, it is reported by 23andMe as testing the C>G variant (not the known, pathogenic C>T variant). The C>G variant is not recognized in dbSNP, and, it would encode a Arg>Gly change of unknown consequence.
C;T
See links via main rs-page.
T;T
See links via main rs-page.
Source and license
Adapted from rs757583846 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.