rs77615401

A SNP in the TNNI3 gene on chromosome 19. Its most notable genotype is A;A: Familial hypertrophic cardiomyopathy, type 7 (possibly)

Gene: TNNI3
Location: Chr 1955,156,239 (GRCh38)
Highest magnitude: 4.0Very important
Tested on: AncestryDNA
Minor allele frequency: <1%

Genotypes

As shown in 23andMe and AncestryDNA files.

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Familial hypertrophic cardiomyopathyCondition

Other TNNI3 SNPs

All TNNI3 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs77615401, also known as c.244C>T, p.Pro82Ser and P82S, represents a mutation in the TNNI3 gene on chromosome 19. A single copy of the rare rs77615401(T) allele is reported to lead to familial hypertrophic cardiomyopathy, type 7. However, the pathogenicity (and penetrance) of this mutation are not certain. The (T) allele is reportedly found in 3% of healthy African-Americans (, and OMIM reports that the authors of that study hypothesize that rs77615401(T) carriers might be at increased risk of late-onset cardiac hypertrophy. This variant is also cited in as being originally misclassified but now very likely to be benign based on an assessment of diverse populations. For more information, see OMIM 191044.0003. This mutation is referred to as i5007729 by 23andMe.

A;A

See discussion at rs77615401

A;G

See discussion at rs77615401

Source and license

Adapted from rs77615401 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.