rs77646904

A SNP in the CFTR gene on chromosome 7. Its most notable genotype is G;T: Carrier for a cystic fibrosis allele

Gene
CFTR
Location
Chr 7117,559,629 (GRCh38)
Highest magnitude
3.0Important
Tested on
Not on consumer chips
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;TMost notableBadCarrier for a cystic fibrosis alleleImportant · 3.0
  2. G;GGoodcommon in complete genomicsTypical · 0.0
  3. C;CGoodcommon in clinvarTypical · 0.0
  4. A;CBadCystic Fibrosis carrierImportant · 3.0

SNPedia records rs77646904 on the minus strand: (A;C), (C;C), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other CFTR SNPs

All CFTR SNPs

Notes

From SNPedia

Notes

Cystic fibrosis; c.1558G>T, p.Val520Phe Note that this SNP is defined on the minus strand, so the G>T change reported in the literature is actually a C>A change for this SNP. named i4000299, i5006075, i5011279 and i5011280 by 23andMe

Source and license

Adapted from rs77646904 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.