rs80338779

A SNP in the CACNA1S gene on chromosome 1. Its most notable genotype is A;C: possibility of Hypokalemic periodic paralysis

Gene
CACNA1S
Location
Chr 1201,066,283 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0
  2. A;CMost notableBadpossibility of Hypokalemic periodic paralysisImportant · 3.0

SNPedia records rs80338779 on the minus strand: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other CACNA1S SNPs

All CACNA1S SNPs

Notes

From SNPedia

Notes

Early onset of hypokalaemic periodic paralysis caused by a novel mutation of the CACNA1S gene.

A;C

Hypokalemic periodic paralysis (hypoKPP) is an autosomal dominant skeletal muscle disorder, so carriers of one rs80338779(T) allele may be at risk for this disorder.

Source and license

Adapted from rs80338779 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.