rs806380

A SNP in the CNR1 gene on chromosome 6. Its most notable genotype is G;G: uncommon. lowest odds of cannabis dependence

Gene
CNR1
Location
Chr 688,154,934 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNormal genotype. slightly higher odds of cannabis dependenceWorth knowing · 2.066% of people
  2. A;GNot ratedNo summary available.Typical · 0.031% of people
  3. G;GMost notableGooduncommon. lowest odds of cannabis dependenceWorth knowing · 2.13% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 66% A;G 31% G;G 3%
  • European ancestry (Utah)A;A 47% A;G 44% G;G 10%
  • Han Chinese (Beijing)A;A 60% A;G 38% G;G 3%
  • Japanese (Tokyo)A;A 69% A;G 31% G;G 0%
  • Yoruba (Nigeria)A;A 89% A;G 11% G;G 0%

Other CNR1 SNPs

All CNR1 SNPs

Notes

From SNPedia

Notes

This snp, located in intron 2 of the central cannabinoid receptor CNR1 gene, has been linked to cannabis dependence. The (G) allele is reported to have a protective effect, and is a defining part of a haplotype that is associated with lower odds of developing cannabis dependence. The (A) allele is more common in all populations studied. Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. (G;G) is also associated with the longest gaze duration for happy faces.

Source and license

Adapted from rs806380 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.