rs1049353

A SNP in the CNR1 gene on chromosome 6. Its most notable genotype is T;T: Likely better response to antidepressants if female

Gene
CNR1
Location
Chr 688,143,916 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
14%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodLikely better response to antidepressants if femaleMinor · 1.02% of people
  2. C;TGoodless likely depressed in response to stressMinor · 1.018% of people
  3. C;CGoodLikely better response to antidepressants if maleMinor · 1.081% of people

SNPedia records rs1049353 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageT;T 2% C;T 18% C;C 81%
  • European ancestry (Utah)T;T 5% C;T 38% C;C 58%
  • Han Chinese (Beijing)T;T 0% C;T 15% C;C 85%
  • Japanese (Tokyo)T;T 0% C;T 14% C;C 86%
  • Yoruba (Nigeria)T;T 0% C;T 3% C;C 97%
  • African ancestry (Southwest US)T;T 0% C;T 18% C;C 83%
  • Chinese (Denver)T;T 0% C;T 13% C;C 87%
  • Gujarati IndianT;T 7% C;T 28% C;C 65%
  • Mexican ancestry (Los Angeles)T;T 0% C;T 17% C;C 83%
  • Maasai (Kenya)T;T 0% C;T 1% C;C 99%
  • TuscanT;T 4% C;T 32% C;C 64%

Conditions, medicines and genes

Other CNR1 SNPs

All CNR1 SNPs

Notes

From SNPedia

Show notes, about 710 words

In this 2013 article titled "Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses", six previous studies of rs1049353 were reviewed. They concluded that the minor A allele may provide protection against depression in response to stress. The gene variants also affected response to antidepressant medication. One study they cited showed that in females, the A allele may confer greater antidepressant responsiveness, but another study showed that in a population of males, the result was opposite and the G allele associated with greater antidepressant responsiveness. Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression.Based on a 2008 study of 256 Caucasian patients being treated for depression, carriers of a rs1049353(G) allele were less likely to respond favorably, particularly if they were females with comorbid anxiety. rs806368(C) together with rs1049353(A) or rs1049353(G) make up a haplotype associated with PTSD, with the C-A haplotype somewhat associated (p=0.04) with higher risk of PTSD and the C-G haplotype associated (p=0.01) with a lower risk of PTSD. Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents. The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men. No association of CNR1 gene variations with susceptibility to schizophrenia. Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis. Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians. Cannabinoid receptor 1 gene association with nicotine dependence. Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. Candidate genes for cannabis use disorders: findings, challenges and directions. Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects. Eating disorders: the current status of molecular genetic research. Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis. G1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2. Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity. Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain. Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women? A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population. Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain. Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression.

T;T

See details at Rs1049353

C;T

see page Rs1049353

C;C

the G allele may increase responsiveness to antidepressants but only in males.

Source and license

Adapted from rs1049353 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.