rs806368

A SNP in the CNR1 gene on chromosome 6. Its most notable genotype is C;C: Associated with Alcohol Dependence; associated with nicotine dependence (female)

Gene
CNR1
Location
Chr 688,140,381 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadAssociated with Alcohol Dependence; associated with nicotine dependence (female)Worth knowing · 2.510% of people
  2. T;TGoodcommon/normalTypical · 0.058% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 10% T;T 58%
  • European ancestry (Utah)C;C 4% T;T 55%
  • Han Chinese (Beijing)C;C 28% T;T 22%
  • Japanese (Tokyo)C;C 28% T;T 27%
  • Yoruba (Nigeria)C;C <1% T;T 86%
  • African ancestry (Southwest US)C;C 0% T;T 88%
  • Chinese (Denver)C;C 29% T;T 25%
  • Gujarati IndianC;C 5% T;T 53%
  • Luhya (Kenya)C;C <1% T;T 86%
  • Mexican ancestry (Los Angeles)C;C 10% T;T 43%
  • Maasai (Kenya)C;C <1% T;T 86%
  • TuscanC;C 4% T;T 63%

Other CNR1 SNPs

All CNR1 SNPs

Notes

From SNPedia

Show notes, about 350 words

risk of the development of substance dependence significantly increased with the number of "G" alleles at rs6454674 and SNP8 (rs806368);T/T genotypes had significant interaction effects (p = .0003 for comorbid drug dependence (DD) and alcohol dependence (AD), .0002 for DD, and .007 for AD). SNP3 and SNP8 together exerted stronger genetic effects on SD (substance dependence) than either did individually. The peak delta values among all the markers were seen for SNP3 and SNP8 (rs806368) rs806368(C) together with rs1049353(A) or rs1049353(G) make up a haplotype associated with PTSD, with the C-A haplotype somewhat associated (p=0.04) with higher risk of PTSD and the C-G haplotype associated (p=0.01) with a lower risk of PTSD. Alcoholic patients with TGT haplotype (corresponding to rs6454674-rs1049353-rs806368 polymorphisms in this order) were less prone to have AD (p = 0.017). TGC haplotype were more likely to develop AD. Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006). These studies provide data to suggest that the CNR1 receptor gene may be significantly associated with impulsivity in SWC Indians. the associations were female specific. Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368(C) was associated with nicotine dependence and FTND score in the 2 samples (P < .001 and P = .009, respectively).

C;C

PMID 22085192 Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence. Alcoholic patients with TGT haplotype (corresponding to rs6454674-rs1049353-rs806368 polymorphisms in this order) were less prone to have AD (p = 0.017). TGC haplotype were more likely to develop AD. PMID 18606954 Cannabinoid receptor 1 gene association with nicotine dependence. the associations were female specific. Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368(C) was associated with nicotine dependence and FTND score in the 2 samples (P < .001 and P = .009, respectively).

References

Source and license

Adapted from rs806368 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.