rs863225322
A SNP in the APC gene on chromosome 5. Its most notable genotype is -;GA: Familial Adenomatous Polyposis
- Gene
- APC
- Location
- Chr 5112,837,566 (GRCh38)
- Highest magnitude
- 6.5Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;GAMost notableBadFamilial Adenomatous Polyposis
- -;GAGABadFamilial Adenomatous Polyposis
- AGAG;AGAGGoodcommon in clinvar
- GA;GAGoodcommon/normal
On SNPedia: (-;GA), (-;GAGA), (AGAG;AGAG), (GA;GA). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other APC SNPs
- rs2229992G;TFamilial Adenomatous PolyposisVery important
- rs62619935C;TFamilial Adenomatous PolyposisVery important
- rs121913331C;TFamilial Adenomatous PolyposisVery important
- rs121913333C;TFamilial Adenomatous PolyposisVery important
- rs137854568C;TFamilial Adenomatous PolyposisVery important
- rs137854569C;GFamilial Adenomatous PolyposisVery important
- rs137854572C;TFamilial Adenomatous PolyposisVery important
- rs137854575A;CFamilial Adenomatous PolyposisVery important
Notes
From SNPedia
Notes
aka c.1970_1971delGA and c.1970_1971delGAGA; both are considered pathogenic in ClinVar for familial adenomatous polyposis
Source and license
Adapted from rs863225322 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.