rs10046

A SNP in the CYP19A1 gene on chromosome 15. Its most notable genotype is G;G: common in clinvar

Gene
CYP19A1
Location
Chr 1551,210,789 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
41%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.039% of people

SNPedia records rs10046 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 39%
  • European ancestry (Utah)G;G 20%
  • Han Chinese (Beijing)G;G 21%
  • Japanese (Tokyo)G;G 29%
  • Yoruba (Nigeria)G;G 68%
  • African ancestry (Southwest US)G;G 67%
  • Chinese (Denver)G;G 22%
  • Gujarati IndianG;G 44%
  • Luhya (Kenya)G;G 56%
  • Mexican ancestry (Los Angeles)G;G 37%
  • Maasai (Kenya)G;G 33%
  • TuscanG;G 31%

Other CYP19A1 SNPs

All CYP19A1 SNPs

Notes

From SNPedia

Show notes, about 430 words

rs10046 is a SNP potentially linked in a gender-specific manner to hypertension rs10046(C;C) associated with miscarriages (P = 0.017) Polymorphisms associated with circulating sex hormone levels in postmenopausal women. Multilocus analysis of SNP and metabolic data within a given pathway. Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk. Sex and body mass index specific regulation of blood pressure by CYP19A1 gene variants. Genome-wide association with bone mass and geometry in the Framingham Heart Study. Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients. Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set. Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome. Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study. A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma. Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women. Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer. Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer. Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China. Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women. Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women. Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure.

Source and license

Adapted from rs10046 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.