rs1062033
A SNP in the CYP19A1 gene on chromosome 15. Its most notable genotype is C;G: increases susceptibility to postmenopausal osteoporosis
- Gene
- CYP19A1
- Location
- Chr 1551,255,741 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 34%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;GMost notableBadincreases susceptibility to postmenopausal osteoporosis
- C;CBadincreases susceptibility to postmenopausal osteoporosis
SNPedia records rs1062033 on the minus strand: (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;G 36% C;C 46%
- European ancestry (Utah)C;G 43% C;C 28%
- Han Chinese (Beijing)C;G 51% C;C 20%
- Japanese (Tokyo)C;G 37% C;C 49%
- Yoruba (Nigeria)C;G 13% C;C 87%
Related
Other CYP19A1 SNPs
- rs78310315C;TUnaffected carrier of an aromatase deficiency mutationImportant
- rs4646A;Acommon in clinvarTypical
- rs10046G;Gcommon in clinvarTypical
- rs700518T;Tcommon in clinvarTypical
- rs700519G;Gcommon in complete genomicsTypical
- rs1902584A;Acommon in complete genomicsTypical
- rs1961177C;Ccommon in complete genomicsTypical
- rs2899472C;Ccommon on affy axiom dataTypical
Notes
From SNPedia
Notes
rs1062033 increases susceptibility to Osteoporosis, postmenopausal for carriers of the G allele Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study.
Source and license
Adapted from rs1062033 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.