rs10168266
A SNP in the STAT4 gene on chromosome 2. Its most notable genotype is C;C: normal risk of Sjogren's syndrome
- Gene
- STAT4
- Location
- Chr 2191,071,078 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 23%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableGoodnormal risk of Sjogren's syndrome
- C;TBad1.44x risk of Sjogren's syndrome
- T;TBad1.44x risk of Sjogren's syndrome
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 60% C;T 33% T;T 7%
- European ancestry (Utah)C;C 62% C;T 34% T;T 4%
- Han Chinese (Beijing)C;C 45% C;T 42% T;T 13%
- Japanese (Tokyo)C;C 59% C;T 30% T;T 11%
- Yoruba (Nigeria)C;C 72% C;T 25% T;T 3%
- African ancestry (Southwest US)C;C 67% C;T 30% T;T 4%
- Chinese (Denver)C;C 36% C;T 50% T;T 14%
- Gujarati IndianC;C 64% C;T 33% T;T 3%
- Luhya (Kenya)C;C 72% C;T 26% T;T 3%
- Mexican ancestry (Los Angeles)C;C 40% C;T 45% T;T 16%
- Maasai (Kenya)C;C 77% C;T 21% T;T 1%
- TuscanC;C 69% C;T 30% T;T 1%
Related
Other STAT4 SNPs
- rs7574865T;T1.69x risk of rheumatoid arthritis; 2.4x risk of SLE; 2.28x risk of Sjögren's syndrome; increased risk of type-1 diabetes; and increased risk of primary biliary cirrhosis.Important
- rs3821236A;A2x higher risk of lupusWorth knowing
- rs10181656G;G1.7x increased SLE riskWorth knowing
- rs3024866G;Gcommon in clinvarTypical
- rs7582694C;C1.71x increased SLE riskTypical
Source and license
Adapted from rs10168266 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.