rs3821236

A SNP in the STAT4 gene on chromosome 2. Its most notable genotype is A;A: 2x higher risk of lupus

Gene
STAT4
Location
Chr 2191,038,032 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x higher risk of lupusWorth knowing · 2.112% of people
  2. A;GBad1.4x higher risk of lupusWorth knowing · 2.043% of people
  3. G;GGoodnormalTypical · 0.046% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 12% A;G 43% G;G 46%
  • European ancestry (Utah)A;A 5% A;G 33% G;G 62%
  • Han Chinese (Beijing)A;A 20% A;G 52% G;G 29%
  • Japanese (Tokyo)A;A 20% A;G 43% G;G 37%
  • Yoruba (Nigeria)A;A 10% A;G 41% G;G 49%
  • African ancestry (Southwest US)A;A 11% A;G 40% G;G 49%
  • Chinese (Denver)A;A 17% A;G 54% G;G 28%
  • Gujarati IndianA;A 4% A;G 35% G;G 61%
  • Luhya (Kenya)A;A 8% A;G 48% G;G 44%
  • Mexican ancestry (Los Angeles)A;A 26% A;G 52% G;G 22%
  • Maasai (Kenya)A;A 5% A;G 39% G;G 57%
  • TuscanA;A 2% A;G 33% G;G 65%

Other STAT4 SNPs

All STAT4 SNPs

Notes

From SNPedia

Notes

CPMC uses this to indicate increased risk of Systemic lupus erythematosus.

A;A

increased risk of Systemic lupus erythematosus.

A;G

increased risk of Systemic lupus erythematosus.

Source and license

Adapted from rs3821236 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.