rs1042173

A SNP in the SLC6A4 gene on chromosome 17. Its most notable genotype is C;C: normal

Gene
SLC6A4
Location
Chr 1730,197,993 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.030% of people
  2. A;CNot ratednormalTypical · 0.037% of people
  3. A;ABadamong alcoholics, likely to be heavier drinkersTypical · 0.033% of people

SNPedia records rs1042173 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 30% A;C 37% A;A 33%
  • European ancestry (Utah)C;C 13% A;C 58% A;A 28%
  • Han Chinese (Beijing)C;C 73% A;C 22% A;A 5%
  • Japanese (Tokyo)C;C 64% A;C 33% A;A 4%
  • Yoruba (Nigeria)C;C 3% A;C 30% A;A 67%
  • African ancestry (Southwest US)C;C 2% A;C 44% A;A 54%
  • Chinese (Denver)C;C 69% A;C 29% A;A 2%
  • Gujarati IndianC;C 33% A;C 44% A;A 24%
  • Luhya (Kenya)C;C 6% A;C 28% A;A 66%
  • Mexican ancestry (Los Angeles)C;C 36% A;C 52% A;A 12%
  • Maasai (Kenya)C;C 1% A;C 18% A;A 81%
  • TuscanC;C 28% A;C 51% A;A 21%

Conditions, medicines and genes

Other SLC6A4 SNPs

All SLC6A4 SNPs

Notes

From SNPedia

Notes

rs1042173 is a SNP in the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 SLC6A4 gene. A study of 275 patients seeking treatment for alcoholism concluded that Caucasians of with the rs1042173(T;T) genotype consumed an average of 11.17 drinks per drinking day, compared with an average of 8.58 for carriers of a rs1042173(G) allele (p = 0.0034). While this held true for both men and women, this association was not seen in Hispanics.

Source and license

Adapted from rs1042173 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.