rs6354
A SNP in the SLC6A4 gene on chromosome 17. Its most notable genotype is G;G: common in clinvar
- Gene
- SLC6A4
- Location
- Chr 1730,222,880 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 21%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs6354 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 6%
- European ancestry (Utah)G;G 3%
- Han Chinese (Beijing)G;G 0%
- Japanese (Tokyo)G;G <1%
- Yoruba (Nigeria)G;G 12%
- African ancestry (Southwest US)G;G 4%
- Chinese (Denver)G;G 0%
- Gujarati IndianG;G 2%
- Luhya (Kenya)G;G 18%
- Mexican ancestry (Los Angeles)G;G 2%
- Maasai (Kenya)G;G 22%
- TuscanG;G 2%
Related
Other SLC6A4 SNPs
- rs25531T;Tshort form of 5-HTTLPR. lower levels of serotonin, slightly less happy, benefits from more supportWorth knowing
- rs140701T;TIncreased risk for anxiety disordersMinor
- rs140700G;GNo summary available.Typical
- rs1042173C;CnormalTypical
- rs2020933A;ANo summary available.Typical
- rs2020942C;Tcommon in complete genomicsTypical
- rs2066713A;Gcommon in complete genomicsTypical
- rs3813034A;Acommon in clinvarTypical
Notes
From SNPedia
Show notes, about 200 words
Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers. Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy. Characterization of a functional polymorphism in the 3' UTR of SLC6A4 and its association with drinking intensity. Serotonin transporter polymorphisms in patients with portopulmonary hypertension. Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples. Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures. Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations.
Source and license
Adapted from rs6354 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.