rs140701

A SNP in the SLC6A4 gene on chromosome 17. Its most notable genotype is T;T: Increased risk for anxiety disorders

Gene
SLC6A4
Location
Chr 1730,211,514 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadIncreased risk for anxiety disordersMinor · 1.532% of people
  2. C;TBadIncreased risk for anxiety disordersMinor · 1.541% of people
  3. C;CGoodNormal risk for anxiety disordersMinor · 1.027% of people

SNPedia records rs140701 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 32% C;T 41% C;C 27%
  • European ancestry (Utah)T;T 12% C;T 52% C;C 35%
  • Han Chinese (Beijing)T;T 71% C;T 24% C;C 5%
  • Japanese (Tokyo)T;T 61% C;T 35% C;C 4%
  • Yoruba (Nigeria)T;T 10% C;T 34% C;C 56%
  • African ancestry (Southwest US)T;T 5% C;T 46% C;C 48%
  • Chinese (Denver)T;T 69% C;T 29% C;C 2%
  • Gujarati IndianT;T 32% C;T 41% C;C 28%
  • Luhya (Kenya)T;T 16% C;T 43% C;C 42%
  • Mexican ancestry (Los Angeles)T;T 32% C;T 53% C;C 16%
  • Maasai (Kenya)T;T 18% C;T 43% C;C 40%
  • TuscanT;T 27% C;T 50% C;C 24%

Conditions, medicines and genes

Other SLC6A4 SNPs

All SLC6A4 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

A study of patients with panic disorder or social anxiety disorder, both moderately heritable anxiety disorders, concluded that the rs140701(A) allele was associated with increased risk for both disorders. This SNP was actually part of a tightly linked haplotype A-A-G (for SNPs rs3794808, rs140701 and rs4583306, respectively) that had 1.7x increased risk for panic disorder (CI: 1.2-2.3).

Source and license

Adapted from rs140701 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.