rs2066713

A SNP in the SLC6A4 gene on chromosome 17. Its most notable genotype is A;G: common in complete genomics

Gene
SLC6A4
Location
Chr 1730,224,647 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;GMost notableGoodcommon in complete genomicsTypical · 0.032% of people

SNPedia records rs2066713 on the minus strand: (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;G 32%
  • European ancestry (Utah)A;G 48%
  • Han Chinese (Beijing)A;G 12%
  • Japanese (Tokyo)A;G 12%
  • Yoruba (Nigeria)A;G 30%
  • African ancestry (Southwest US)A;G 56%
  • Chinese (Denver)A;G 11%
  • Gujarati IndianA;G 32%
  • Luhya (Kenya)A;G 29%
  • Mexican ancestry (Los Angeles)A;G 41%
  • Maasai (Kenya)A;G 32%
  • TuscanA;G 44%

Notes

From SNPedia

Show notes, about 230 words

Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans. Gene-gene interaction associated with neural reward sensitivity. Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples. Development and validation of a high-throughput screening method for two polymorphisms in the serotonin transporter gene. Association and gene-gene interaction of SLC6A4 and ITGB3 in autism. Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population. A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Single nucleotide polymorphisms of the serotonin transporter gene in migraine--an association study. Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations.

Source and license

Adapted from rs2066713 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.