rs1056827
A SNP in the CYP1B1 gene on chromosome 2. Its most notable genotype is C;C: common in clinvar
- Gene
- CYP1B1
- Location
- Chr 238,075,034 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 32%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1056827 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 2 HapMap populations.
- AverageC;C 84%
- Han Chinese (Beijing)C;C 75%
- Japanese (Tokyo)C;C 93%
Related
Other CYP1B1 SNPs
- rs28936700C;TCarrier of a primary congenital glaucoma mutationImportant
- rs28936701A;GCarrier of a primary congenital glaucoma mutationImportant
- rs1056836C;C0.3x decreased risk for prostate cancerWorth knowing
- rs9282671T;Tsmall chance of slightly increasing risk for a form of glaucomaMinor
- rs1056837A;Acommon in clinvarTypical
- rs1800440T;Tcommon on affy axiom dataTypical
Notes
From SNPedia
Notes
Also known as 355G>T or A119S, the T allele is associated with gene variants CYP1B1*2, CYP1B1*6 and CYP1B1*7.
Source and license
Adapted from rs1056827 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.