rs28936701
A SNP in the CYP1B1 gene on chromosome 2. Its most notable genotype is A;G: Carrier of a primary congenital glaucoma mutation
- Gene
- CYP1B1
- Location
- Chr 238,070,949 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadCarrier of a primary congenital glaucoma mutation
- C;CNot ratedNo summary available.
SNPedia records rs28936701 on the minus strand: (C;C), (C;T), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in one HapMap population.
- Luhya (Kenya)G;G 99% A;G <1% C;C 0%
Related
Other CYP1B1 SNPs
- rs28936700C;TCarrier of a primary congenital glaucoma mutationImportant
- rs1056836C;C0.3x decreased risk for prostate cancerWorth knowing
- rs9282671T;Tsmall chance of slightly increasing risk for a form of glaucomaMinor
- rs1056827C;Ccommon in clinvarTypical
- rs1056837A;Acommon in clinvarTypical
- rs1800440T;Tcommon on affy axiom dataTypical
Notes
From SNPedia
Notes
aka c.1405C>T (p.Arg469Trp or R469W)
A;G
Unaffected in absence of a second CYP1B1 gene mutation
Source and license
Adapted from rs28936701 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.