rs1137617
A SNP in the KCNH2 gene on chromosome 7. Its most notable genotype is A;T: potential cardiac arrhythmia
- Gene
- KCNH2
- Location
- Chr 7150,951,110 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1137617 on the minus strand: (A;T), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other KCNH2 SNPs
- rs189014161C;GLong QT syndrome; other possible cardiac issuesVery important
- rs9333649C;TRomano-Ward Long QT SyndromeVery important
- rs12720441A;GRomano-Ward Long QT SyndromeVery important
- rs28928904A;TRomano-Ward Long QT SyndromeVery important
- rs121912505C;TRomano-Ward Long QT SyndromeVery important
- rs121912506C;TRomano-Ward Long QT SyndromeVery important
- rs121912507C;TRomano-Ward Long QT SyndromeVery important
- rs121912508A;GRomano-Ward Long QT SyndromeVery important
Notes
From SNPedia
Notes
rs1137617 represents a variant in the KCNH2 gene on chromosome 7. There are several reported alleles for this SNP. The rs1137617(C) and (T) alleles, as reported in the dbSNP/minus orientation, are both common and encode the same amino acid (tyrosine; TYR). However, the rs1137617(A) allele is a nonsense mutation, encoding a stop codon, and it is considered pathogenic for cardiac arrhythmia by a (single) source in ClinVar. This is potentially inherited in a dominant manner.
A;T
see discussion at rs1137617
G;G
this is a silent and likely benign polymorphism
A;G
considered a benign polymorphism
Source and license
Adapted from rs1137617 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.