rs28928904

A SNP in the KCNH2 gene on chromosome 7. Its most notable genotype is A;T: Romano-Ward Long QT Syndrome

Gene
KCNH2
Location
Chr 7150,951,615 (GRCh38)
Highest magnitude
5.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TNot ratedNo summary available.Typical · 0.0
  2. A;TMost notableBadRomano-Ward Long QT SyndromeVery important · 5.0
  3. A;GBadRomano-Ward Long QT SyndromeVery important · 5.0
  4. C;CBadpossibly increased susceptibility to long QT syndromeImportant · 3.0
  5. A;CBadRomano-Ward Long QT SyndromeVery important · 5.0
  6. A;AGoodcommon in complete genomicsTypical · 0.0

SNPedia records rs28928904 on the minus strand: (A;A), (A;T), (C;T), (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other KCNH2 SNPs

All KCNH2 SNPs

Notes

From SNPedia

Notes

rs28928904, also known as I593R or Ile593Arg, is a SNP in the KCNH2 gene on chromosome 7. A 1996 publication reports that the rs28928904(G) allele is associated with long QT syndrome 2. This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.

C;C

see discussion at rs28928904

Source and license

Adapted from rs28928904 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.