rs1205

Although somewhat lacking in statistical power, several reports have linked rs1205, a UTR mutation known as CRP4 in the C-reactive protein CRP to the autoimmune disorder SLE, systemic lupus erythematosus. The risk allele in dbSNP orientation is (T). PMID 14645206, PMID 15897982 C-reactive protein (CRP) levels obesity rs1205(G) allele had significantly higher CRP levels than noncarriers in a dose-dependent manner suggesting a possible association with fat localization 23andMe blog each rs1205(T) lowered CRP by 20% but no association with heart disease. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration. Association study between C-reactive protein genes and ischemic stroke in Japanese subjects. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese. Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study). Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study. C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study. Genome-wide association with select biomarker traits in the Framingham Heart Study. DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study. Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study. Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies. Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families. Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study. Systemic inflammation, genetic susceptibility and lung function. Bayesian meta-analysis of genetic association studies with different sets of markers. Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach. Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations. Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity. Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study. Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort. C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population. C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults. C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein. Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins. Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. Usefulness of Mendelian randomization in observational epidemiology. Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring. C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects. Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily). Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms. Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics. C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.