rs3093059

A SNP in the CRP gene on chromosome 1. Its most notable genotype is G;G: associated with elevated C-reactive protein levels and hypertension

Gene
CRP
Location
Chr 1159,715,346 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadassociated with elevated C-reactive protein levels and hypertensionWorth knowing · 2.06% of people

SNPedia records rs3093059 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 6%
  • European ancestry (Utah)G;G <1%
  • Han Chinese (Beijing)G;G 2%
  • Japanese (Tokyo)G;G 2%
  • Yoruba (Nigeria)G;G 12%
  • African ancestry (Southwest US)G;G 7%
  • Chinese (Denver)G;G 4%
  • Gujarati IndianG;G 0%
  • Luhya (Kenya)G;G 20%
  • Mexican ancestry (Los Angeles)G;G 0%
  • Maasai (Kenya)G;G 17%
  • TuscanG;G 1%

Notes

From SNPedia

Show notes, about 360 words

A study of 12,854 Japanese subjects replicated the association between rs3093059 and serum CRP levels (p = 3.5 x 10e-21). Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk rs3093059 rs3091244 A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration. C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study. Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families. Bayesian meta-analysis of genetic association studies with different sets of markers. Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations. Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort. C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population. C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

G;G

CRP gene codes for C-reactive protein, a marker of inflammation. C-reactive protein (CRP) gene polymorphisms, CRP levels and risk of incident essential hypertension: findings from an observational cohort of Han Chinese. (2012). nature.com Plasma CRP levels were independently associated with the development of hypertension. The minor alleles of rs1130864 (P<0.001) and rs3093059 (P<0.001) were significantly associated with elevated CRP levels. Plasma CRP levels were substantially associated with common genetic variants in the CRP gene and can predict the development of hypertension.

Source and license

Adapted from rs3093059 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.