rs3093061

A SNP in the CRP gene on chromosome 1. Its most notable genotype is T;T: normal risk

Gene
CRP
Location
Chr 1159,715,192 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodnormal riskTypical · 0.0
  2. C;TNot ratednormal risk?Typical · 0.0
  3. C;CNot rated0.37-0.49x reduced risk for SLETypical · 0.0

SNPedia records rs3093061 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3093061 is a SNP in the promoter of the C-reactive protein CRP gene. rs3093061 associated with SLE and functional haplotypes containing rs3091244/rs3093062 A study of ~1,000 patients with systemic lupus erythematosus found that in both populations (Caucasian and African-American) studied, the rs3093061(G;G) genotype had a significantly reduced risk compared to the more common (A;A) genotype. In African-Americans, the odds ratio was 0.49 (CI: 0.37-0.65, p=6.4x10e-7), and in Caucasians, the odds ratio was 0.37 (CI: 0.24-0.56, p=2.3x10e-6). Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

Source and license

Adapted from rs3093061 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.