rs1800947

A SNP in the CRP gene on chromosome 1. Its most notable genotype is G;G: lower CRP levels

Gene
CRP
Location
Chr 1159,713,648 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
4%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedlower CRP levelsTypical · 0.00% of people
  2. C;GNot ratedlower CRP levelsTypical · 0.08% of people
  3. C;CGoodnormalTypical · 0.092% of people

SNPedia records rs1800947 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 0% C;G 8% C;C 92%
  • European ancestry (Utah)G;G 0% C;G 14% C;C 86%
  • Han Chinese (Beijing)G;G 0% C;G 13% C;C 87%
  • Japanese (Tokyo)G;G 0% C;G 7% C;C 93%
  • Yoruba (Nigeria)G;G 0% C;G 0% C;C 100%

Other CRP SNPs

All CRP SNPs

Notes

From SNPedia

Notes

Although somewhat lacking in statistical power, several reports have linked rs1800947, a synonymous mutation known as CRP2 in the C-reactive protein CRP to the autoimmune disorder SLE, systemic lupus erythematosus. The risk allele in dbSNP orientation is (C). PMID 14645206, PMID 15897982, PMID 18216863 news C linked to lower CRP levels

Source and license

Adapted from rs1800947 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.