rs121908829
A SNP in the TMEM127 gene on chromosome 2. Its most notable genotype is C;T: Hereditary PGL/PCC Syndrome
- Gene
- TMEM127
- Location
- Chr 296,254,078 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadHereditary PGL/PCC Syndrome
- C;CGoodcommon in clinvar
SNPedia records rs121908829 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TMEM127 SNPs
- rs121908818C;THereditary PGL/PCC SyndromeVery important
- rs121908821C;GHereditary PGL/PCC SyndromeVery important
- rs121908825A;CHereditary PGL/PCC SyndromeVery important
- rs121908826G;THereditary PGL/PCC SyndromeVery important
- rs121908827A;GHereditary PGL/PCC SyndromeVery important
- rs121908828C;THereditary PGL/PCC SyndromeVery important
- rs121908830A;GHereditary PGL/PCC SyndromeVery important
- rs121908831-;GCTGCTCTCAGAGAHereditary PGL/PCC SyndromeVery important
Notes
From SNPedia
Notes
Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas.
Source and license
Adapted from rs121908829 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.