rs121908830
A SNP in the TMEM127 gene on chromosome 2. Its most notable genotype is A;G: Hereditary PGL/PCC Syndrome
- Gene
- TMEM127
- Location
- Chr 296,254,050 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in complete genomics
- A;GMost notableBadHereditary PGL/PCC Syndrome
SNPedia records rs121908830 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TMEM127 SNPs
- rs121908818C;THereditary PGL/PCC SyndromeVery important
- rs121908821C;GHereditary PGL/PCC SyndromeVery important
- rs121908825A;CHereditary PGL/PCC SyndromeVery important
- rs121908826G;THereditary PGL/PCC SyndromeVery important
- rs121908827A;GHereditary PGL/PCC SyndromeVery important
- rs121908828C;THereditary PGL/PCC SyndromeVery important
- rs121908829C;THereditary PGL/PCC SyndromeVery important
- rs121908831-;GCTGCTCTCAGAGAHereditary PGL/PCC SyndromeVery important
Notes
From SNPedia
Notes
Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.
Source and license
Adapted from rs121908830 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.