rs121964853

A SNP in the TPM3 gene on chromosome 1. Its most notable genotype is T;T: Nemaline Myopathy 1

Gene
TPM3
Location
Chr 1154,176,194 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadNemaline Myopathy 1Very important · 4.0
  2. G;TBadNemaline Myopathy 1Worth knowing · 2.0
  3. G;GGoodcommon in clinvarTypical · 0.0

SNPedia records rs121964853 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other TPM3 SNPs

All TPM3 SNPs

Notes

From SNPedia

Notes

Mutations in TPM3 are a common cause of congenital fiber type disproportion.

Source and license

Adapted from rs121964853 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.