rs12498742

A SNP in the SLC2A9 gene on chromosome 4. Its most notable genotype is A;A: 1.25 increased risk for gout

Gene
SLC2A9
Location
Chr 49,942,428 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.25 increased risk for goutMinor · 1.555% of people
  2. G;GGoodnormal reduced risk of goutTypical · 0.010% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 55% G;G 10%
  • European ancestry (Utah)A;A 58% G;G 4%
  • Han Chinese (Beijing)A;A 99% G;G 0%
  • Japanese (Tokyo)A;A 97% G;G 0%
  • Yoruba (Nigeria)A;A 21% G;G 30%
  • African ancestry (Southwest US)A;A 26% G;G 19%
  • Chinese (Denver)A;A 91% G;G 0%
  • Gujarati IndianA;A 62% G;G 4%
  • Luhya (Kenya)A;A 17% G;G 26%
  • Mexican ancestry (Los Angeles)A;A 45% G;G 12%
  • Maasai (Kenya)A;A 33% G;G 16%
  • TuscanA;A 55% G;G 4%

Conditions, medicines and genes

Other SLC2A9 SNPs

All SLC2A9 SNPs

Notes

From SNPedia

Notes

Each copy of the minor (G) allele appears to confer reduced risk for gout based on combined data from over 140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), replicating an association reported earlier for a linked SNP in this gene.

Source and license

Adapted from rs12498742 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.