rs7442295
A SNP in the SLC2A9 gene on chromosome 4. Its most notable genotype is A;A: ~4x higher risk for hyperuracemia
- Gene
- SLC2A9
- Location
- Chr 49,964,756 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 22%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBad~4x higher risk for hyperuracemia
- A;GBad~2x higher risk for hyperuracemia
- G;GNot ratednormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 61% A;G 32% G;G 7%
- European ancestry (Utah)A;A 60% A;G 37% G;G 3%
- Han Chinese (Beijing)A;A 99% A;G <1% G;G 0%
- Japanese (Tokyo)A;A 98% A;G 2% G;G 0%
- Yoruba (Nigeria)A;A 32% A;G 52% G;G 16%
- African ancestry (Southwest US)A;A 32% A;G 54% G;G 14%
- Chinese (Denver)A;A 92% A;G 9% G;G 0%
- Gujarati IndianA;A 66% A;G 29% G;G 5%
- Luhya (Kenya)A;A 36% A;G 50% G;G 15%
- Mexican ancestry (Los Angeles)A;A 45% A;G 43% G;G 12%
- Maasai (Kenya)A;A 49% A;G 45% G;G 6%
- TuscanA;A 62% A;G 34% G;G 4%
Related
Notes
From SNPedia
Show notes, about 130 words
rs7442295 is a SNP in the SLC2A9 gene; this gene encodes a glucose transporter. Based on an initial study of 1900+ hypertensive Caucasian Europeans, the more common allele rs7442295(A) allele was associated with higher serum urate and hyperuracemia (defined as urate >0.4 mMol/l), with a reported odds ratio of 1.89 (CI: 1.36-2.61, p=5 x 10 -5 ). This was also seen in an associated meta-analysis conducted with a broadly representative population and using a surrogate SNP, rs6449213, which is in fairly tight linkage (r 2 =0.88) with rs7442295. To put it another way, 79% of white Europeans carry one or two alleles leading to higher serum urate levels. Each copy leads to an average increase of 0.02mMol/l, and, an ~doubling of risk for hyperuracemia.
Source and license
Adapted from rs7442295 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.