rs16890979
A SNP in the SLC2A9 gene on chromosome 4. Its most notable genotype is T;T: lower systolic blood pressure, serum uric acid and gout risk
- Gene
- SLC2A9
- Location
- Chr 49,920,543 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe
- Minor allele frequency
- 22%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGood3.4x risk of gout
- C;TBad1.7x risk of gout
- T;TMost notableGoodlower systolic blood pressure, serum uric acid and gout risk
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 59% C;T 33% T;T 8%
- European ancestry (Utah)C;C 59% C;T 38% T;T 3%
- Han Chinese (Beijing)C;C 99% C;T 2% T;T 0%
- Japanese (Tokyo)C;C 98% C;T 2% T;T 0%
- Yoruba (Nigeria)C;C 29% C;T 54% T;T 17%
- African ancestry (Southwest US)C;C 30% C;T 51% T;T 19%
- Chinese (Denver)C;C 93% C;T 7% T;T 0%
- Gujarati IndianC;C 71% C;T 25% T;T 4%
- Luhya (Kenya)C;C 30% C;T 53% T;T 17%
- Mexican ancestry (Los Angeles)C;C 45% C;T 41% T;T 14%
- Maasai (Kenya)C;C 33% C;T 58% T;T 8%
- TuscanC;C 61% C;T 35% T;T 4%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 210 words
rs16890979 has been found to be associated with gout in several independent studies. It may be a variation in the SLC2A9 gene, which is more commonly known as GLUT9. In a study of Old Order Amish, rs16890979 - which is also known as the missense mutation Val253Ile - was found as the most significantly associated SNP during a follow-up study based on a genome wide association study. Each copy of the minor allele, rs16890979(T), was associated with a decrease of 0.47 mg/dl in the uric acid level (CI: 0.31-0.63, p = 1.43 x 10e-11). See also: 23andMe blog gout Independently, a large study totaling 7,699 participants in the Framingham cohort and 4,148 participants in the Rotterdam cohort was conducted, with genome-wide significant SNPs then replicated in 11,000+ Caucasian and ~4,000 African-American individuals who took part in the study of Atherosclerosis Risk in Communities (ARIC). This study calculated an odds ratio of 0.59 per T allele (CI: 0.52-0.68, p=7.0x10e-14). A genetic score comprised of this SNP plus 2 others may stratify risk for gout. rs16890979 was found to be associated with gout based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.
Source and license
Adapted from rs16890979 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.