rs1255998

A SNP in the ESR2 gene on chromosome 14. Its most notable genotype is G;G: common in complete genomics

Gene
ESR2
Location
Chr 1464,227,153 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
35%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in complete genomicsTypical · 0.037% of people

SNPedia records rs1255998 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 37%
  • European ancestry (Utah)G;G 84%
  • Han Chinese (Beijing)G;G 18%
  • Japanese (Tokyo)G;G 27%
  • Yoruba (Nigeria)G;G 18%

Other ESR2 SNPs

All ESR2 SNPs

Notes

From SNPedia

Notes

Among women, rs8179176, rs9340799, rs1256065, and rs1256030 were associated with likelihood of developing cognitive impairment. In men, rs728524, rs1255998, and rs1256030 were associated with cognitive impairment.

Source and license

Adapted from rs1255998 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.