rs2987983

A SNP in the ESR2 gene on chromosome 14. Its most notable genotype is G;G: 1.2x increased risk of prostate cancer

Gene
ESR2
Location
Chr 1464,296,935 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.2x increased risk of prostate cancerWorth knowing · 2.022% of people
  2. A;GBad1.2x increased risk of prostate cancerWorth knowing · 2.043% of people
  3. A;ANot ratednormal riskTypical · 0.035% of people

SNPedia records rs2987983 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 22% A;G 43% A;A 35%
  • European ancestry (Utah)G;G 11% A;G 40% A;A 50%
  • Han Chinese (Beijing)G;G 12% A;G 47% A;A 41%
  • Japanese (Tokyo)G;G 8% A;G 44% A;A 48%
  • Yoruba (Nigeria)G;G 48% A;G 37% A;A 14%
  • African ancestry (Southwest US)G;G 46% A;G 32% A;A 23%
  • Chinese (Denver)G;G 11% A;G 45% A;A 44%
  • Gujarati IndianG;G 16% A;G 48% A;A 37%
  • Luhya (Kenya)G;G 36% A;G 49% A;A 15%
  • Mexican ancestry (Los Angeles)G;G 3% A;G 41% A;A 55%
  • Maasai (Kenya)G;G 33% A;G 49% A;A 18%
  • TuscanG;G 14% A;G 45% A;A 41%

Conditions, medicines and genes

Other ESR2 SNPs

All ESR2 SNPs

Notes

From SNPedia

Notes

In one large Swedish study, men with one or two rs2987983(C) alleles were reported to be at somewhat increased (odds ratio 1.22) risk for Prostate cancer compared to men homozygous for the wild type rs2987983(T) allele, however the risk can be reduced by adding phytoestrogens to the diet.

G;G

This genotype is at a slightly (1.2X) increased risk of prostate cancer Recommendation: To reduce the risk of prostate cancer, eat a diet rich in phytoestrogens

A;G

This genotype is at increased risk of prostate cancer Recommendation: To reduce the risk eat a diet rich in phytoestrogens such as flax seed

A;A

This is the typical form, exhibiting normal risk for prostate cancer to learn more visit rs2987983

Source and license

Adapted from rs2987983 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.