rs12720461

A SNP in the CYP1A2 gene on chromosome 15. Its most notable genotype is C;T: carrier of one CYP1A2*1K_-729C>T allele, decreased CYP1A2 activity

Gene
CYP1A2
Location
Chr 1574,749,010 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.099% of people
  2. C;TMost notableBadcarrier of one CYP1A2*1K_-729C>T allele, decreased CYP1A2 activityWorth knowing · 2.0<1% of people
  3. T;TBadCYP1A2*1K_-729C>T homozygote, decreased CYP1A2 activityWorth knowing · 2.0<1% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 7 HapMap populations.

  • AverageC;C 99% C;T <1% T;T <1%
  • European ancestry (Utah)C;C 100% C;T 0% T;T 0%
  • Han Chinese (Beijing)C;C 98% C;T 0% T;T 2%
  • Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%
  • Gujarati IndianC;C 99% C;T 1% T;T 0%
  • Maasai (Kenya)C;C 99% C;T <1% T;T 0%
  • TuscanC;C 97% C;T 3% T;T 0%

Other CYP1A2 SNPs

All CYP1A2 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs12720461 is a SNP in the CYP1A2 gene. The rs12720461(T) allele defines the CYP1A2*1K_-729C>T variant.

Source and license

Adapted from rs12720461 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.