rs28399424
A SNP in the CYP1A2 gene on chromosome 15. Its most notable genotype is C;T: carrier of one CYP1A2*6 allele
- Gene
- CYP1A2
- Location
- Chr 1574,754,828 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 2 HapMap populations.
- AverageC;C 99% C;T 1% T;T 0%
- Luhya (Kenya)C;C 99% C;T <1% T;T 0%
- Mexican ancestry (Los Angeles)C;C 98% C;T 2% T;T 0%
Related
Other CYP1A2 SNPs
- rs12720461C;Tcarrier of one CYP1A2*1K_-729C>T allele, decreased CYP1A2 activityWorth knowing
- rs72547513A;CNo summary available.Worth knowing
- rs762551A;AFaster caffeine metabolism in smokers and heavy coffee consumersMinor
- rs2069526G;GCYP1A2*1K_-739T>G homozygoteTypical
- rs2470890C;CCYP1A2_1545T>C homozygoteTypical
- rs3743484G;Gcommon genotypeTypical
Genosets
- Gs157More stimulated by coffeeWorth knowing
- Gs159CYP1A2 fast metabolizerWorth knowing
- Gs158CYP1A2 normal metabolizerTypical
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs28399424, also known as 5090C>T or R431W, is a SNP in the CYP1A2 gene. The rs28399424(T) allele defines the CYP1A2*6 decreased activity variant.
Source and license
Adapted from rs28399424 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.