rs2470890

A SNP in the CYP1A2 gene on chromosome 15. Its most notable genotype is C;C: CYP1A2_1545T>C homozygote

Gene
CYP1A2
Location
Chr 1574,755,085 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedCYP1A2_1545T>C homozygoteTypical · 0.060% of people
  2. C;TNot ratedcarrier of one CYP1A2_1545T>C alleleTypical · 0.030% of people
  3. T;TGoodnormalTypical · 0.010% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 60% C;T 30% T;T 10%
  • European ancestry (Utah)C;C 13% C;T 43% T;T 45%
  • Han Chinese (Beijing)C;C 71% C;T 26% T;T 3%
  • Japanese (Tokyo)C;C 61% C;T 35% T;T 4%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%
  • African ancestry (Southwest US)C;C 74% C;T 26% T;T 0%
  • Chinese (Denver)C;C 72% C;T 27% T;T <1%
  • Gujarati IndianC;C 76% C;T 22% T;T 2%
  • Mexican ancestry (Los Angeles)C;C 52% C;T 36% T;T 12%
  • Maasai (Kenya)C;C 60% C;T 35% T;T 5%
  • TuscanC;C 26% C;T 46% T;T 28%

Other CYP1A2 SNPs

All CYP1A2 SNPs

Notes

From SNPedia

Notes

rs2470890 is a SNP in the CYP1A2 gene. The rs2470890(C) allele defines the CYP1A2_1545T>C variant. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

Source and license

Adapted from rs2470890 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.