rs16754
A SNP in the WT1 gene on chromosome 11. Its most notable genotype is T;T: common in clinvar
- Gene
- WT1
- Location
- Chr 1132,396,399 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 32%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs16754 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 52%
- European ancestry (Utah)T;T 73%
- Han Chinese (Beijing)T;T 7%
- Japanese (Tokyo)T;T 13%
- Yoruba (Nigeria)T;T 77%
- African ancestry (Southwest US)T;T 79%
- Chinese (Denver)T;T 11%
- Gujarati IndianT;T 36%
- Luhya (Kenya)T;T 83%
- Mexican ancestry (Los Angeles)T;T 45%
- Maasai (Kenya)T;T 76%
- TuscanT;T 70%
Related
Other WT1 SNPs
- rs28941778C;TDenys-Drash syndromeVery important
- rs28941779A;GFrasier syndrome mutationVery important
- rs28942089A;GDenys-Drash syndromeVery important
- rs121907900A;GWilms tumor susceptibility (predicted)Very important
- rs121907906A;GWilms tumor susceptibility (predicted)Very important
- rs121907908C;TWilms tumor susceptibility (predicted)Very important
- rs121907909A;GWilms tumor susceptibility (predicted)Very important
- rs121907911G;TWilms tumor susceptibility (predicted)Very important
Notes
From SNPedia
Notes
Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population. Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells. Single-nucleotide polymorphism in WT1 gene in a hyperplastic intralobar nephrogenic rest with botryoid protrusion. No prognostic impact of the WT1 gene single nucleotide polymorphism rs16754 in pediatric acute myeloid leukemia. Wilms' tumor 1 single-nucleotide polymorphism rs16754 does not predict clinical outcome in adult acute myeloid leukemia. WT1 mutations and polymorphisms in Southeast Asian acute myeloid leukemia.
Source and license
Adapted from rs16754 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.